Machine Learning Coffee seminar: "Studying mutational processes in cancer" Ville Mustonen

Weekly seminars held jointly by Aalto University and the University of Helsinki.

Helsinki region machine learning researchers will start our week by an exciting machine learning talk. The aim is to gather people from different fields of science with interest in machine learning. Porridge and coffee is served at 9:00 and the talk will begin at 9:15. The venue for this talk is seminar room Exactum D123, Kumpula.

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Studying mutational processes in cancer

Ville Mustonen
Professor of Mathematics and Natural Science, University of Helsinki

Abstract:

Somatic mutations in cancer have accumulated during its evolution and are caused by different exposures to carcinogens and therapeutic agents, as well as, intrinsic errors that occur during DNA replication. Analysing a set of cancer samples jointly allows to explain their somatic mutations as a linear combination of (to be learned) mutational signatures. In this presentation I will discuss the problem of learning mutational signatures from cancer data using probabilistic modelling and nonnegative matrix factorisation. I further describe our on going work using mutational signatures in the context of drug response prediction and extensions of the basic model to explicitly include DNA repair processes.

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